Benzenepropanamide, N-1-isoquinolinyl-4-methoxy-N-(3R)-3-piperidinyl-
R-IMPP
CAS: 2133832-83-2
Molecular Formula: C24H27N3O2
Benzenepropanamide, N-1-isoquinolinyl-4-methoxy-N-(3R)-3-piperidinyl- - Names and Identifiers
| Name | R-IMPP |
| Synonyms | R-IMPP PF-00932239 (R-IMPP) Benzenepropanamide, N-1-isoquinolinyl-4-methoxy-N-(3R)-3-piperidinyl- |
| CAS | 2133832-83-2 |
Benzenepropanamide, N-1-isoquinolinyl-4-methoxy-N-(3R)-3-piperidinyl- - Physico-chemical Properties
| Molecular Formula | C24H27N3O2 |
| Molar Mass | 389.49 |
| Density | 1.186±0.06 g/cm3(Predicted) |
| Boling Point | 594.4±50.0 °C(Predicted) |
| Solubility | DMSO : 41 mg/mL (105.27 mM) |
| pKa | 9.14±0.10(Predicted) |
| Storage Condition | -20°C |
| In vitro study | R-IMPP promotes the uptake of LDL-R in liver cancer cells by increasing the level of LDL-C, without affecting the level of transferrin secretion. R-IMPP does not reduce PCSK9 transcription or increase PCSK9 degradation, but rather results in a transcript-dependent inhibition of PCSK9 translation. R-IMPP had weak anti-PCSK9 secretion activity, IC50 = 4.8 μm. In the recombinant CHO-K1 cells, it did not affect the intracellular ATP level, nor reduce the control protein, secretion of secreted alkaline phosphatase. R-IMPP inhibitory activity with stereo specificity. |
Benzenepropanamide, N-1-isoquinolinyl-4-methoxy-N-(3R)-3-piperidinyl- - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.567 ml | 12.837 ml | 25.675 ml |
| 5 mM | 0.513 ml | 2.567 ml | 5.135 ml |
| 10 mM | 0.257 ml | 1.284 ml | 2.567 ml |
| 5 mM | 0.051 ml | 0.257 ml | 0.513 ml |
Last Update：2024-01-02 23:10:35
Benzenepropanamide, N-1-isoquinolinyl-4-methoxy-N-(3R)-3-piperidinyl- - Reference Information
| biological activity | R-IMPP is an inhibitor of PCSK9 secretion, IC50 is 4.8 μM. |
| target | TargetValue PCSK9 () |
| Target | Value |
| In vitro study | R-IMPP promote the absorption of LDL-C in liver cancer cells by increasing the level of LDL-R without affecting the level of transferrin secretion. R-IMPP does not reduce PCSK9 transcription or increase PCSK9 degradation, but causes transcript-dependent inhibition of PCSK9 translation. R-IMPP has weak anti-PCSK9 secretion activity, IC50 = 4.8 μM, and does not affect intracellular ATP level in recombinant CHO-K1 cells, nor does it reduce the secretion of control protein and secretory alkaline phosphatase. The inhibitory activity of R-IMPP is stereospecific. |
Last Update：2024-04-09 15:16:37
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Product Name: R-IMPP Visit Supplier Webpage Request for quotationCAS: 2133832-83-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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